Ischemia/reperfusion (I/R) injury induces an inflammatory response and production of reactive oxygen species (ROS), which affects the organs remote to the sites of I/R. Renal injury associated with liver disease is a common clinical problem which leads to morbidity and mortality in patients with acute renal failure. This study aimed to assess the hepatic changes during various periods of reperfusion after renal I/R injury. Forty male rats were subjected to either sham operation or to 45-minute ischemia followed by 2, 4 and 24 hours of reperfusion. Liver function (ALT/AST) were found to be significantly increased after 45 min ischemia followed by 2, 4 and 24 hours of reperfusion but, the increase in the 4 and 24 hours groups was much higher than that in the 2h reperfusion group. Hepatic MDA was significantly increased after all three periods of reperfusion. Also, hepatic TAC was significantly decreased, as compared with the sham group; the highest change in hepatic MDA and TAC content was observed at 24 hours reperfusion after 45 min of renal ischemia than other reperfusion groups. Finally, hepatic histopathological examinations have confirmed the biochemical results, the severity of hepatic injury after 24 hours reperfusion was higher than other reperfusion groups. Renal I/R injury was associated with hepatic damage at various reperfusion periods but the severity of liver injury at 24 hours reperfusion was higher as compared with the other reperfusion groups.
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